Trial design. Enrolled patients received a first course of R-CHOP that was not preceded by NGR-hTNF, while the other 5 courses were preceded by NGR-hTNF. Each of the lines corresponds to a treatment course. The first column represents gadolinium-enhanced MRI (brain MRI) performed for response assessment; the second column represents cerebral DCE-MRI and SPECT performed before treatment course (day 0) and used as baseline data; the third and fourth columns represent treatment courses; the fifth column represents DCE-MRI and SPECT performed after treatment and used to assess changes in BBB permeability. Arrows represent collection of CSF and plasma samples.