Pathology of HV biopsy specimens. (A-B) Skin biopsy specimen from patient 5 showing multiloculated intraepidermal vesicles with reticular degeneration and necrotic epidermal keratinocytes and a mixed inflammatory reaction with neutrophils and mononuclear cells; no viral cytopathic changes were observed. The dermis showed perivascular, periadnexal, and interstitial mononuclear cells with a predominance of small lymphocytes throughout the thickness of the dermis (hematoxylin and eosin stain [(B) higher power]). (C-D) Terminal ileum and Peyer’s patches with reactive follicle (C; hematoxylin and eosin stain) and numerous EBV-positive cells (D; in situ hybridization for Epstein-Barr encoded RNA) in patient 5. (E-F) Skin biopsy specimen from patient 16 stained for CD3 (E) and Epstein-Barr encoded RNA (F; EBER). Original magnification ×100 (A,C), ×200 (D-F), ×400 (B).