Prognostic markers for survival and disease progression in patients with neurotoxicity. (A) Sagittal and axial positron emission tomography-CT images show a paraspinal mass (arrows) with high-intensity contrast uptake consistent with lymphoma (left) and complete response 1 month after CAR T-cell infusion (right). Kaplan-Meier estimates of overall survival (B) and progression-free survival (C) in our cohort. Tick marks indicate censored patients. Kaplan-Meier estimates of overall survival and progression-free survival for different prognostic markers. Curves are given for patients with low- or high-grade neurotoxicity (D), LDH <400 U/L or ≥400 U/L at CAR T-cell infusion (E), and ≤10 or >10 days of steroid use (F). Tick marks indicate censored patients.