Timeline and biomarkers of neurotoxicity (NTX). (A) Swimmer plot shows the kinetics of NTX in each patient through 30 days after CAR T-cell infusion (n = 25). Each row represents 1 patient; the highest grade of neurotoxicity recorded on each day is color-coded. Three patients died within 30 days of CAR T-cell infusion after severe neurologic symptoms. Median time to first fever ≥38°C for patients with (blue dotted line) grade 1-2 neurotoxicity and (red dotted line) grade 3-4 neurotoxicity is indicated. (B) Number of patients with each grade (Gr) of CRS and neurotoxicity. (C-D) Serum levels of the acute-phase proteins CRP (C) and ferritin (D) in relationship to serum levels at CAR T-cell infusion. Ratio is shown for patients with grade 1-2 neurotoxicity (gray) and grade 3-4 neurotoxicity (blue) 2 days before neurotoxicity; at onset of neurotoxicity; and at days 2, 4, 6, 8, and 10 after onset of neurotoxicity. Vertical black dotted line indicates onset of neurotoxicity. Median ratio and interquartile range are given.