IRF8⁺ LMPPs are biased toward cDC1 differentiation. Schematic representation of hematopoietic development where some early progenitors are already precommitted to certain lineages (adapted from Guilliams et al⁵ ). Expression of IRF8 in LMPPs (green) biases differentiation toward cDC1s. Some IRF8⁺ LMPPs also give rise to cDC2s and pDCs, whereas a few IRF8⁺ LMPPs will give rise to other lineages, including monocytes, neutrophils, T cells, or B cells. CLP, common lymphoid progenitor; CMP, common myeloid progenitor; HSC, hematopoietic stem cell; ILC, innate lymphoid cell; NK, natural killer.