Figure 1.
![Figure 1. Effect of the FLT3-ITD knock-in allele on APL initiation by PML/RARA. (A) Overall survival and acute leukemia-free survival of lethally irradiated recipients transplanted with P/R-FLT3ki, FLT3ki, or P/R bone marrow cells. (B) Strategy to obtain P/R and P/R-FLT3ki cells in a FVB background, subsequently tagged with GFP by retroviral transduction. (C) GSEA analysis for 50 hallmark gene sets between P/R and P/R-FLT3ki mice. Transcriptomic analysis performed on RNA extracted from GFP-positive leukemic cells. Only significant pathways were represented (with false discovery rate q values [FDR.q.val] <0.05) according to normalized enrichment score (NES) value.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/133/13/10.1182_blood-2018-07-866095/3/blood866095f1.png?Expires=1722771490&Signature=4m~~OqaIgp5zVv5Eu38VADwILmdwrgOl9ccMlzSomEmQkJzq3xLT0p8a069xG73L521aDK063GLSA~M2k3CFXmQMLdmtCF4iW7BDdu2sfjZd~jq-j7jPUw3H25yb~9t5axstRR9RQaUiHbArbguDYXlqwdhfjiAXydIYoU2gEQMTr8RT5DP8fSclg7po2sn3HiNZe0C0~wLiDVvjQD-QrESNQHDLkPnc56oIHsJw-SzxNGh-u0rY7eTjXppQGm~1N~oPoR8-Lx3PntIrIci-PYQ39CGUljsAceXRWBcxMHosOCfmimXhSChXGLul9PSAZ11CPXhzmW9Wkhsz-qpTeQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of the FLT3-ITD knock-in allele on APL initiation by PML/RARA. (A) Overall survival and acute leukemia-free survival of lethally irradiated recipients transplanted with P/R-FLT3ki, FLT3ki, or P/R bone marrow cells. (B) Strategy to obtain P/R and P/R-FLT3ki cells in a FVB background, subsequently tagged with GFP by retroviral transduction. (C) GSEA analysis for 50 hallmark gene sets between P/R and P/R-FLT3ki mice. Transcriptomic analysis performed on RNA extracted from GFP-positive leukemic cells. Only significant pathways were represented (with false discovery rate q values [FDR.q.val] <0.05) according to normalized enrichment score (NES) value.