Multivariate analysis with clinical and biological variables. Gene mutations were included in the Cox regression analysis if they were detected in ≥10 patients and had a univariate P value ≤ .10 for OS, not adjusted for multiple comparisons. The model was stratified for center treatment strategy. KIT-mutated patients with a VAF ≥25% and FLT3-ITD patients with AR ≥0.35 were defined as KIT^high or FLT3-ITD^high.