Methylation classes in JMML. Unsupervised cluster analysis of 1000 most variably methylated CpG dinucleotides (represented in rows with the methylation values coded in shades of color from blue [0%] to red [100%]) in 147 patients (columns) identifies 3 classes with characteristic differences in the distribution of Ras pathway mutations (genotype) and probability of relapse after HSCT. Adapted from Lipka et al⁸⁶  with permission.