Figure 2.
![Proposed model for the role of Ca2+signaling in the commitment to becoming procoagulant. Platelet activators trigger an initial increase in [Ca2+]cyt that varies between platelets (1). This action will lead to variation in [Ca2+]mito (2), putting some above the threshold for mPTP opening. A supramaximal [Ca2+]cyt signal is triggered in these platelets (3), committing them to becoming procoagulant. Variation in the initial [Ca2+]cyt is therefore converted into 2 distinct subpopulations with distinct [Ca2+]cyt signals, leading to an all-or-nothing commitment to becoming procoagulant.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/4/1/10.1182_bloodadvances.2019000182/3/advancesadv2019000182f2.png?Expires=1724159533&Signature=mouhKgdMJAYNoq~QiyiLAbFSMuBWj1143cArjqSbyzGO6kjxo9PAqGwEXTexbVpUJAcQKAeWqRYba1bN9WidwniqAC1sohGqxF-JCE~f8oTKcs1IVCExzbFjZKQsA6F3cXJ~Qryq3e8l~5o4D9uXlkDeT7HoVjpYTqNQ-Reqj2V7sqgYyBCxROR4snhutPq0eXZM70bj0K~1AhZaHf5sPEwFJFteLWzL3zZTnJNv6jHjAth-3DI8wxFs6Bl-CaVXb~qhg4~piaJvs-BFcqAXRo~B-5-9-c9LN47SOrY0OuPAq3eC65DiSawp-UsvEo5o9drPoWlXAdCQDu8OACceVw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Proposed model for the role of Ca2+signaling in the commitment to becoming procoagulant. Platelet activators trigger an initial increase in [Ca2+]cyt that varies between platelets (1). This action will lead to variation in [Ca2+]mito (2), putting some above the threshold for mPTP opening. A supramaximal [Ca2+]cyt signal is triggered in these platelets (3), committing them to becoming procoagulant. Variation in the initial [Ca2+]cyt is therefore converted into 2 distinct subpopulations with distinct [Ca2+]cyt signals, leading to an all-or-nothing commitment to becoming procoagulant.