EM, stratified by the median, and clinical outcomes. (A-B) Greater class II EM in the GVH direction was associated with reduced incidence of relapse and improved RFS, and these associations remained significant in multivariate analysis. (C-D) Greater class II EM in the HVG direction was associated with longer time to neutrophil and platelet engraftment, and these associations remained significant in multivariate analysis. (E-F) Class I and II EM in the GVH direction were not associated with aGVHD of any grade.