APOBEC3G levels increased in 75% of evaluable patients after bortezomib administration. APOBEC3G was measured by using western blot on PBMC from 12 patients. (A) PBMCs from both baseline and day 8 were lysed, and proteins were separated by using sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Gel lanes were reordered in the figure to group according to bortezomib dose level. (B) APOBEC3G level was quantified by using ImageJ software (National Institutes of Health, Bethesda, MD), and the results are presented as a fold change in the level of APOBEC3G normalized to actin.