Most common treatment-emergent AEs in the integrated safety analysis (N = 330). AEs of any grade occurring in >15% of patients or grade 3/4 AEs occurring in >3% of patients are shown. *Muscle spasm and constipation included 1 (<1%) grade 3/4 AE each, and febrile neutropenia included 1 (<1%) grade 1/2 (AEs not shown).