CALCRL, LSP1 and CD109 expression levels (median split) stratify survival in adult patients with AML (discovery series). (A-C) Kaplan-Meier estimates of EFS and OS. Survival curves were compared using a log-rank (Mantel-Cox) test. (D) Median PI values within each 0.5 PI value range plotted against probability of survival to time point X, with plot of best-fit by second-order polynomial function. (E) CALCRL, LSP1, and CD109 gene expression levels (raw data) in patients with AML.