IR of overall and new-onset CV-AEs and AT-AEs per 100 person-years in all patients treated with frontline TKI treatments: trends per year. (A) The IR of patients with overall AEs per 100 person-years shows that the incidence of vascular AEs was highest in the first year of TKI therapy. (B) The IR of patients with new-onset CV-AEs per 100 person-years shows that the incidence of CV-AEs was highest in the first year of TKI therapy. (C) Similarly, the IR of patients with AT-AEs per 100 person-years shows that the incidence of AT-AEs was highest in the first year after TKI therapy and continued to occur at later years. P < .001 in all panels.