Figure 3.
Figure 3. Significant sST2-donor SNP association β values and hazard ratios for aGVHD death and infection death. Plots show the relationship of donor SNPs with sST2 levels in donors and death from aGVHD death (A) and infection (B). SNPs are shown in the y-axis with rs identification (ID) and the effect allele, in order by chromosome position. The point colors indicate the P values of the SNP for each analysis. Only SNPs that pass multiple test correction are included in the panel. The left column shows the coefficient β values with confidence intervals (CIs) of donor SNP associations with sST2 plasma/serum levels. The middle column shows subdistribution hazard ratios and CIs from competing risk models with aGVHD death as primary cause. The right column shows results from competing risk models of aGVHD death as the primary cause without infection. (B) The left panel shows the coefficient β values with CIs of donor SNP associations with sST2 plasma/serum levels. The middle panel shows subdistribution hazard ratios from a cox proportional model and competing risk model (HRs) and CIs of competing risk models with death caused by infection. The right column shows results from competing risk models with death due to infection among patients who did not experience aGVHD III-IV.

Significant sST2-donor SNP association β values and hazard ratios for aGVHD death and infection death. Plots show the relationship of donor SNPs with sST2 levels in donors and death from aGVHD death (A) and infection (B). SNPs are shown in the y-axis with rs identification (ID) and the effect allele, in order by chromosome position. The point colors indicate the P values of the SNP for each analysis. Only SNPs that pass multiple test correction are included in the panel. The left column shows the coefficient β values with confidence intervals (CIs) of donor SNP associations with sST2 plasma/serum levels. The middle column shows subdistribution hazard ratios and CIs from competing risk models with aGVHD death as primary cause. The right column shows results from competing risk models of aGVHD death as the primary cause without infection. (B) The left panel shows the coefficient β values with CIs of donor SNP associations with sST2 plasma/serum levels. The middle panel shows subdistribution hazard ratios from a cox proportional model and competing risk model (HRs) and CIs of competing risk models with death caused by infection. The right column shows results from competing risk models with death due to infection among patients who did not experience aGVHD III-IV.

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