Influence of CHARGE variants on FVIII PK phenotypic quartiles. The frequency of genotypes were compared between patients in the quartile with the shortest FVIII half-life (n = 11) and patients in the quartile with the longest FVIII half-life (n = 11) (A) and between patients in the quartile with the slowest rate of FVIII clearance (n = 11) and patients with the fastest rate of FVIII clearance (n = 11) (B). *P ≤ .05.