Figure 2.
![Figure 2. Influence of rare and low-frequency VWF D′D3 variants on VWF:Ag and VWF:FVIIIB. (A) Comparison of VWF:Ag between study subjects heterozygous for a rare or low-frequency VWF D′D3 variant and subjects homozygous for the reference allele [excluding the p.(Thr789Ala)/p.(Tyr795=) variants]. (B) Comparison of VWF:FVIIIB between study subjects heterozygous for a rare or low-frequency VWF D′D3 variant and subjects homozygous for the reference allele [excluding the p.(Thr789Ala)/p.(Tyr795=) variants]. Data are mean ± standard error. ○, wild-type; ▪, p.(Arg852Glu); □, p.(Arg826Lys). *P ≤ .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/134/11/10.1182_blood.2019000190/7/bloodbld2019000190f2.png?Expires=1722732864&Signature=L-zmF0rm7akT9hkT9XG4a709mRRlwoi4V6cKGx0eXoPnoTY1kFdwZsYQUHd3IJpssfAc4bBgc0uyJ4xykMDIPD9fxJU7pt6~lnyPCEDB6xP6hvEwALX1KcFiNMz1ZQ8G1ppBBmhc4DQYU7vNbrqNe5qNMmr5za8UhN0JwoTXGXk4kyuBBB24JxcmarHJpeT4uMn4Ub2WoVyzoTq0unkGU29GPdEPDfBN-0qgc3AXVKiq3XnpPvGSOzuHh3PFJh~ovpFQB5Os2Z~r3wQtFbsF9eBSYHu9Iff5wH-GLiTQlgI9yDM9w4xP8jnECGtl-kRFGBSv6yOH1KFXLNcfsepgHw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Influence of rare and low-frequency VWF D′D3 variants on VWF:Ag and VWF:FVIIIB. (A) Comparison of VWF:Ag between study subjects heterozygous for a rare or low-frequency VWF D′D3 variant and subjects homozygous for the reference allele [excluding the p.(Thr789Ala)/p.(Tyr795=) variants]. (B) Comparison of VWF:FVIIIB between study subjects heterozygous for a rare or low-frequency VWF D′D3 variant and subjects homozygous for the reference allele [excluding the p.(Thr789Ala)/p.(Tyr795=) variants]. Data are mean ± standard error. ○, wild-type; ▪, p.(Arg852Glu); □, p.(Arg826Lys). *P ≤ .05.