Integration of ChIP and expression analyses. (A) Venn diagram showing numbers of common and unique binding peaks for SCL and LYL1 in the human megakaryocyte cell line MEG-01. (B) De novo motif discovery at common SCL/LYL1 binding sites in MEG-01 cells identifies significant enrichment for GATA, E-BOX, and ETS motifs and RUNX. (C) Venn diagram showing overlap of downregulated genes for Pf4Sclc-KO, Lyl1-KO, and DKO cells with mouse homologs of the common SCL/LYL1-binding sites identified in MEG-01 cells. (D) Read peak plot for ChIP-seq reads in MEG-01 cells and primary human megakaryocytes (GSE24674) displayed in the University of California Santa Cruz genome browser shows overlapping binding of SCL and LYL1 near the GATA1 gene.