Comparison of mutational frequencies between histopathological/pathogenetically related entities. (A) Comparison of mutation frequencies for putative PMBL driver genes identified by MutSigCV between our PMBL cohort and the DLBCL cohort published by Reddy et al⁴⁸  (genes were required to be mutated in at least 3 cases). (B) Comparison of mutation frequencies in DLBCL driver genes as identified in Chapuy et al⁴  between our PMBL cohort and the DLBCL cohorts published by Reddy et al and Chapuy et al; EZH2 is marked by an asterisk in panels A and B, as the only gene with no significant difference in terms of mutational frequency between DLBCL and PMBL. (C) Mutational frequencies in cHL and PMBL are comparable for genes shown to be recurrently mutated in cHL as defined by Tiacci et al.⁴⁹  Statistically significant differences in mutation frequency between the two cohorts are marked with an asterisk. For all comparisons, silent as well as 5′- and 3′-UTR mutations were excluded.