Mutational patterns and correlation of genetic alterations in PMBL. (A) Statistically significant mutual exclusivity or co-occurrence among the identified PMBL driver genes using pairwise Fisher’s exact test (multiple testing correction was performed according to the Benjamini-Hochberg method). (B) Highly significant examples of mutual exclusivity (SOCS1 and CXCR5, GNA13 and IL4R, STAT6 and CISH) are shown as pairwise comparisons. Each column represents a case, and mutated cases are highlighted in colors indicating specific mutation types as specified in the key. Absolute numbers of mutated cases are provided on the right, and the frequency plot on top of each subpanel provides the number of mutations in driver genes per case.