Serum cytokines and CRP levels in subjects developing toxicities. (A) IFN-γ (IFN-g), (B) IL-10, (C) IL-6, and (D) CRP concentrations increase after infusion of CAR T cells (2 days following ASCT) in all patients. Both IFN-γ and IL-10 increased significantly at day 5 post-ASCT in subjects developing a neurotoxicity plus or minus CRS than in subjects without toxicities (P < .001 and P = .07, respectively). There was a trend for significant increase of IL-6 concentration in subjects with CRS than in subjects without CRS. Increases in CRP levels were similar in subjects with and without toxicities.