GSK3 inhibition or deletion in lymphoma cells leads to cell cycle arrest in G2/M. (A) Cell cycle profile of 3 representative cell lines Jeko, Mino, and OCI-Ly3 after a 24-hour treatment with 0, 1.0, or 2.0 μM 9-ING-41. (B) Cell cycle profiles of parental Ly-1 cells and GSK3α-, GSK3β-, and GSK3αβ-knockout subclones. Inset: western blot image showing the depletion of GSK3α and GSK3β protein in the knockout Ly-1 subclones.