Prevalence of grade ≥3 AEs of clinical interest over time (ITT population). Prevalence was determined by the proportion of patients with a given AE (which can be an existing event or new onset of an event) during each yearly interval. Multiple onsets of the same AE term within a given yearly interval were counted once, and the same AE term continuing across several yearly intervals were counted in each of the intervals. *Defined as any hemorrhagic event grade ≥3 or in severity or that results in one of the following: intraocular bleeding causing vision loss, need for a transfusion of ≥2 U red blood cells or equivalent, hospitalization, or prolongation of hospitalization.