In refugees, the identification of new patients with severe hemoglobinopathy might result from the intersection of patients with acute events and screening programs for individuals from endemic areas. (A) Type and frequency of acute and nonacute events in refugees allowing the identification of a severe hemoglobinopathy in Italy between 2014 and 2017. *Other includes cardiopathy (n = 1), seizures (n = 1), splenic infarction and thrombosis of central retinal vein (n = 1), left gonalgia in severe gonarthrosis and joint deformities in septic arthritis outcomes (n = 1), inconsolable crying of a baby (n = 1), and genetic counseling for the second pregnancy of a mother (n = 1). (B) Percentages or patients screened, in a second-level refugee center with the new point-of-care screening device, as a way of fast-tracking the individuals with SCD, differentiated by genotype, as a function of nationality.