Numbers and country of origin of refugees in Italy with new identified severe hemoglobinopathy. (A) Numbers of total refugees in Italy, refugees from the sub-Saharan area, and refugees from Syria in the period between 2014 and 2017. (B) Map showing the influxes of refugees identified with hemoglobinopathies (SCD or TDT) after their arrival in Italy between 2014 and 2017. Countries of origin are shown in dark gray. The number of refugees from a country is proportional to the width and saturation of each line. (C) Numbers of patients with hemoglobinopathies (SCD or TDT) differentiated by genotype, as a function of nationality.