Schematic representation of the pathway for the generation of PGE₂-G and its activation of P2Y6 receptors. COX-2 oxidizes 2-AG to generate PGE₂-G, a putative agonist of P2Y6 receptors. This pathway is blocked by inhibition of COX-2 by R-flurbiprofen or blocking P2Y6 receptors with the antagonist MRS2578.