NFE2 mutations are present in MPN and patients with de novo AML. (A-B) Schematic representation of the NFE2 protein indicating mutations detected in (A) patients with MPN and (B) patients with de novo AML. (A-B) Patients with MPN reported in Jutzi et al¹⁰  and Lundberg et al,³⁴  as well as in patients with MPN analyzed by B.C. and A. Vannuchi and P. Guglielmelli (personal communication). Patients with AML: 749 patients from HOVON trials, as well as 400 patients from AML-SG trials.^11-13  Color code: red, insertion and deletion mutations causing a frameshift; orange, small in frame deletions; blue, point mutations. Details are given in supplemental Table 1. NES, nuclear export sequence; NLS, nuclear localization sequence.