Bone marrow cells lacking PHF6 repopulate the hematopoietic system more efficiently and retain stem cell capacity through serial transplantations. (A) Schematic diagram showing the experimental design for competitive serial hematopoietic transplantation. (B) Percentages of donor cell contribution to long-term reconstitution 4 months after transplantation in each round of serial transplantation. n = 5 control (Phf6^+/Y;Tie2-cre^Tg/+), n = 6 Phf6^lox/Y;Tie2-cre^Tg/+ donors. All donors were 8 weeks old. Data were arcsine transformed and averaged by donor prior to analysis with a 2-tailed Student t test and are displayed as mean ± SEM. BM, bone marrow.