The trend of biochemical parameters and symptom score after treatment. Change in median hemoglobin level (A), IL-6 (B), CRP (C), IgG (D), and symptom score (E) over time in responders (blue line) and nonresponders (red line). Median and range are labeled with dots and dashed lines except for month 36 (only 1 patient was followed to month 36, so no range is available).