Survival and blood pressure according to treatment assignments. Kaplan-Meier curves illustrate survival after initiation of ponatinib (30 mg/kg per day) or vehicle (sham treatment) in wild-type C57Bl/6 mice (A) and ApoE^−/− mice on a WSD (B). Tail-cuff systolic blood pressure was measured in awake wild-type (C) and ApoE^−/− mice on a WSD (D) in animals that were acclimatized to the procedure prior to initiation of therapy. *P < .05 vs vehicle. BP, blood pressure.