Rearrangements of the immunoglobulin loci in BL. (A) Translocations (shown in center) between the MYC locus (chromosome 8) and the IGH (chromosome 14), IGK (chromosome 2), or IGL (chromosome 22) loci in tumors with WGS data (N = 106). The inner track displays the rainfall plot for simple somatic mutations in these regions. Mutations that overlap AICDA recognition sites (RGYW) are shown in red. (B) Percentage of EBV-positive and EBV-negative BL (N = 117) and DLBCL (N = 323) tumors with RNA-seq data that use the given immunoglobulin V genes to encode their most clonal BCRs (ie, with the highest clonal fraction). V genes that are clonal in fewer than 4 BL tumors are not displayed. Within each group, V genes are ordered from top to bottom on the basis of decreasing overall frequency in the BL cohort.