Gadolinium resolution on brain MRI correlates with donor neutrophil recovery in cALD patients. (A) Example of a T1-weighted MRI showing a classic ring of gadolinium contrast (arrow; left panel). An MRI exhibiting complete gadolinium contrast resolution 30 days after HCT (right panel). (B) Percentage of patients having complete gadolinium resolution at the indicated time points after HCT. The blue columns represent patients with neutrophil recovery and single HCT, and the red columns represent patients who failed to engraft. (C) Day of neutrophil recovery for patients with contrast resolution at the indicated cumulative time points post-HCT. (D) Frequency of contrast resolution between patients who had ANC recovery ≤ 16 days (faster) vs >16 days (slower). (E) Frequency of contrast resolution in cALD patients with higher CD15 chimerism (70-100%) vs lower CD15 chimerism (<70%) at 60 days post-HCT. (F) Table of pre-HCT and HCT parameters with univariate analysis P values. Variables used in the multivariate analysis model are in bold type. All P values were derived using Fisher’s exact test.