Maea deletion impairs BM erythropoiesis under steady state and stress conditions. (A) Deletion efficiency of Maea by Csf1r-Cre in spleen macrophages as determined by FACS (n = 7). (B) Quantification of spleen RPM numbers (n = 8). (C) RBC, hematocrit (HCT), and reticulocyte measurements of control and Maea^Csf1r-Cre mice over the course of 4 weeks after splenectomy (n = 9). (D) RBC, HCT, and reticulocyte assessment in splenectomized control and Maea^Csf1r-Cre mice after PHZ-induced hemolytic anemia (n = 9 per group, pooled from 2 independent experiments). Data are shown as mean plus or minus SEM. *P < .05, **P < .01, ***P < .001, ****P < .0001 by unpaired Student t test. SPX, splenectomy.