Low postoperative plasma fibrinogen levels are associated with LD and mortality in patients undergoing liver resection. Plasma fibrinogen levels were measured 1 day before resection (PRE OP) and on POD 1 and POD 5 in 312 patients. (A) Plasma fibrinogen levels in patients who did (magenta boxplots, n = 32) or did not (light blue boxplots, n = 280) develop LD after resection. (B) Plasma fibrinogen levels in patients who did (lime green boxplots, n = 8) or did not (mustard boxplots, n = 304) suffer from postoperative mortality within 90 days after resection. Receiver-operating characteristic curve analysis of plasma fibrinogen levels on (C) POD 1 and (D) POD 5 to predict postoperative liver dysfunction. (E) Incidence of morbidity, postoperative LD, and mortality according to the defined cutoff value for plasma fibrinogen levels on POD 1 (300 mg/dL). Panels A and B show boxplots with median, 25% to 75% interquartile ranges, and minimum and maximum fibrinogen levels. Panel E shows incidence (in percentage) of morbidity, LD, and mortality. *P < .05. AUC, area under the curve.