Kaplan-Meier curves based on a hierarchical model for OS incorporating CK, TP53abs (deletion of chromosome 17p and/or TP53 mutations), and the expression of somatically hypermutated (M-CLL) or unmutated (U-CLL) immunoglobulin heavy variable genes (IGHV). High-CK (≥5 aberrations, red line) exhibits the shortest OS followed by cases with TP53abs and 3 or 4 aberrations (low-CK and intermediate-CK, respectively; low-CK/intermediate-CK/TP53abs, green line), non-CK cases with TP53abs (non-CK/TP53abs, purple line), and non-CK/non-TP53abs cases with unmutated IGHV genes (non-CK/non-TP53abs/U-CLL, black line). Patients with the longest OS are those with non-CK/TP53abs and mutated IGHV genes (M-CLL), as well as patients with CK and +12,+19 (non-CK/non-TP53abs/M-CLL–CK,+12,+19, blue line). P values for all pair comparisons are provided with an inset table in which the colored cells indicate the respective subgroups based on the color of each Kaplan-Meier curve.