Kaplan-Meier curves for OS. (A) Patients with CK (≥3 aberrations, red line) vs non-CK cases (0-2 aberrations, blue line) in the entire cohort. The observed crossover can be explained by the few “events” at the tail of the CK curve, where mostly censored cases are included. (B) Patients with FISH-normal/idel(13q) detected by FISH who carry CK (≥3 aberrations, red line) vs non-CK FISH-normal/idel(13q) cases (blue line). (C) Patients with CK and +12,+19 (red line) vs CLL with CK (green line) and the remaining non-CK CLL (blue line). (D) Patients with CK and +12,+19 carrying mutated IGHV genes (M-CLL, blue line) vs the remaining M-CLL with CK (red line).