Kaplan-Meier curves based on a hierarchical model for OS incorporating complex karyotype (CK), TP53abs (deletion of chromosome 17p and/or TP53 mutations), and somatic hypermutation status of the IGH genes. High-CK (≥5 aberrations, red line) exhibits the shortest OS followed by cases with TP53abs and 3 or 4 aberrations (low CK and intermediate CK, respectively, low CK/intermediate CK/TP53abs, green line), non-CK cases with TP53abs (non-CK/TP53abs, purple line), and non-CK/non-TP53abs cases with unmutated IGHV genes (non-CK/non-TP53abs/U-CLL, black line). Patients with the longest OS are those with non-CK/TP53abs and mutated IGHV genes (M-CLL) as well as patients with CK and +12,+19 (non-CK/non-TP53abs/M-CLL-CK, +12,+19, blue line). P values for all pair comparisons are provided in the table, where the colored cells indicate the respective subgroups based on the color of each Kaplan-Meier curve. See Figure 4 in the article by Baliakas et al that begins on page 1205.