Figure 1.
Effect of deficiency of FIX or FXI on thrombin generation in murine plasma. (A) Thrombin generation in murine FIX-deficient PPP was initiated with low and high concentrations of hTF. Thrombin generation in mFXI-deficient PPP collected in the absence of CTI was initiated with silica (B) or low and high doses of hTF (C). Thrombin generation in mFXI-deficient PPP collected in the presence of CTI was initiated with silica (D) or low and high doses of hTF (E). Thrombin generation in mFXI-deficient PRP collected in the presence of CTI was initiated with silica (F) or low and high doses of hTF (G). Data are presented as individual values with means ± 95% confidence intervals. *P < .05, 2-way analysis of variance with post hoc Bonferroni test (FIX+/+ vs FIX−/−); **P < .001, 1-way analysis of variance with post hoc Bonferroni test (FXI+/+ and FXI+/− vs FXI−/−).

Effect of deficiency of FIX or FXI on thrombin generation in murine plasma. (A) Thrombin generation in murine FIX-deficient PPP was initiated with low and high concentrations of hTF. Thrombin generation in mFXI-deficient PPP collected in the absence of CTI was initiated with silica (B) or low and high doses of hTF (C). Thrombin generation in mFXI-deficient PPP collected in the presence of CTI was initiated with silica (D) or low and high doses of hTF (E). Thrombin generation in mFXI-deficient PRP collected in the presence of CTI was initiated with silica (F) or low and high doses of hTF (G). Data are presented as individual values with means ± 95% confidence intervals. *P < .05, 2-way analysis of variance with post hoc Bonferroni test (FIX+/+ vs FIX−/−); **P < .001, 1-way analysis of variance with post hoc Bonferroni test (FXI+/+ and FXI+/− vs FXI−/−).

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