ATF6 deletion in hepatocytes decreases systemic fibrinolytic activity, bleeding time, and time to thrombotic carotid occlusion. Liver Plat mRNA (A), plasma tPA protein concentration (B), plasma tPA activity (C), tail bleeding time (D), and time to occlusive carotid arterial thrombosis (E) induced by photochemical injury in Atf6^fl/fl mice treated with AAV8-TBG-LacZ or AAV8-TBG-Cre. Horizontal lines in dot-density plots indicate mean values. *P < .05, **P < .01, ***P < .01, 2-tailed Student t test (n = 7 mice per each group).