Silencing of hepatocyte Plat mRNA in HC-DACH1–KO mice decreases liver tPA, plasma tPA, and systemic fibrinolytic activity. Liver Plat mRNA and plasma tPA protein concentration and activity (A) and tail bleeding time and time to occlusive carotid arterial thrombosis induced by photochemical injury (B) in Dach1^fl/fl mice administrated LacZ or Cre as in Figure 1, together with control AAV8-H1 virus (Ctrl) or AAV8-H1-shPlat. Horizontal lines indicate mean values. *P < .05, **P < .01, 1-way analysis of variance, followed by the Tukey test (n = 6 mice per each group).