Prognostic relevance of correct GE-classification in the cohort of localized-stage FL. Kaplan-Meier plots with log-rank P values for FFS for patients with a GE signature of advanced-stage FL (III/IV) identified by the Lasso model (A) and Ridge regression (B) in 88 patients from the localized-stage FL (I/II) cohort with clinical data. (A) FFS for patients with Lasso-based signature STS1 ≥ 13.672 (n = 85; 39 events) and STS1 < 13.672 (n = 3; 3 events) (B) FFS for patients with Ridge-based signature STS0 ≥ 2.932 (n = 85; 39 events) and STS0 < 2.932 (n = 3;3 events). There were too few events for an OS evaluation.