Prognostic relevance of correct GE-classification in the training cohort. Kaplan-Meier plots with log-rank P values for FFS (A,C) and OS (B,D) in patients with a GE profile for localized-stage FL (I/II) identified by the Lasso model (A-B) and Ridge regression (C-D) in the training cohort of advanced-stage FL (III/IV) treated without R. FFS and OS for patients with Lasso-based signature STS1 ≥ 13.672 (n = 248; 169 and 78 events for FFS and OS, respectively) and STS1 < 13.672 (n = 21; 10 and 5 events for FFS and OS, respectively) (A-B). FFS (C) and OS (D) for patients with Ridge-based signature STS0 ≥ 2.932 (n = 249; 171 and 81 events for FFS and OS, respectively) and STS0 < 2.932 (n = 20; 8 and 2 events for FFS and OS, respectively).