MPD is independent of CD8 T cell activation. β2m^KOCD11c^ΔMHCII mice were assessed by flow cytometry. WT and CD11c^ΔMHCII mice are shown for comparative purposes. (A) Spleen weight and (B) percentage of peripheral mononuclear neutrophils (PMN) (CD11b^high Gr1⁺) among total splenocytes at 12 weeks (n = 11, 13, 6), 20 weeks (n = 22, 16, 3), 30 weeks (n = 22, 16, 5), and 1 year (n = 23, 25, 5) of age. (C) Absolute number of PMN among total splenocytes at 12 weeks (n = 11, 13, 6), 20 weeks (n = 22, 16, 3), 30 weeks (n = 18, 14, 5), and 1 year (n = 22, 23, 5) of age. (D) Absolute number of myeloid precursor-like cells among total splenocytes at 12 weeks (n = 11, 13, 6), 20 weeks (n = 22, 16, 2), 30 weeks (n = 12, 7, 5), and 1 year (n = 22, 23, 5) of age. Mean ± standard error of the mean and individual data points are shown.