Figure 1.
Schematic model of RUNX1, RUNX1T1, and RUNX1-RUNX1T1 domains. The translocation t(8;21)(q22;q22) generates a fusion gene consisting of the RUNX1 gene from chromosome 21 and the RUNX1T1 gene from chromosome 8. AD, activation domain; ID, inhibitory domain; RHD, runt homology domain; TAD, transactivation domain.

Schematic model of RUNX1, RUNX1T1, and RUNX1-RUNX1T1 domains. The translocation t(8;21)(q22;q22) generates a fusion gene consisting of the RUNX1 gene from chromosome 21 and the RUNX1T1 gene from chromosome 8. AD, activation domain; ID, inhibitory domain; RHD, runt homology domain; TAD, transactivation domain.

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