Combination of copanlisib and venetoclax is highly synergistic in a DLBCL xenograft model. (A) Bioluminescence of NSG mice xenotransplanted with luciferized mCherry+ LY1 DLBCL cells treated with vehicle (black; n = 8), copanlisib alone (red, 12 mg/kg IV, 2 days on/5 days off on days 1, 2, 8, 9, 15, 16; n = 9), ABT-199 alone (blue, 100 mg/kg orally, daily on days 1-21; n = 7), or combination copanlisib and ABT-199 (purple; n = 8). Treatment was stopped at day 21. Asterisks indicate P values <.05 in a 1-sided Student t test. Error bars represent SEM. (B) Representative prone bioluminescence images from panel A. (C) Kaplan-Meier survival plot of the treated cohorts. The P values were obtained by log-rank test.