Figure 5.
![Figure 5. Combination of copanlisib and venetoclax is synergistic in in vitro DLBCL models. Induction of apoptosis (percentage of viable [annexin V/PI–negative] cells) after 96-hour exposure to the combination of copanlisib (0-250 nM) and ABT-199 (0-250 nM). Results show average viability plus or minus SEM from 2 biological replicates. Synergy visualized as median CI. CI < 1 indicates synergy. (A-C,E-F,H) Synergy; (I-J) single agent venetoclax activity; (D,G) antagonism.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/133/1/10.1182_blood-2018-08-872465/9/blood872465f5.png?Expires=1724830246&Signature=Enf9IbLdhr8dIfFu15wkimMfdKo4ptVh66HsLLE1X0dSLnpUWQY5FlhORInR2kpncEBopzgtAdpvoHeQfXIB9ROwRdgTeQ7AeibggCGIcZZ-cDAYMlHgiw5uK2C0ql5AxlcOlyMjhU4G1vGgJDmbGZsJBSgTfNzJAiEXo4wN0Xg~SpepodCyEEsVsEzUwsFk1dbqlCkDntaRvSdMirT5Yb8JSD5QLLeT3vai-NJLfdgI8xjU1MRHK96Qnt0jaoqvPR2kfZnFKwkJg3X6S94~v9OWYiPnc473HsMGITcK8~rlakcldgbWymkC-TxzknLOUulaZFeCVcVjdqJkRYYPrA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Combination of copanlisib and venetoclax is synergistic in in vitro DLBCL models. Induction of apoptosis (percentage of viable [annexin V/PI–negative] cells) after 96-hour exposure to the combination of copanlisib (0-250 nM) and ABT-199 (0-250 nM). Results show average viability plus or minus SEM from 2 biological replicates. Synergy visualized as median CI. CI < 1 indicates synergy. (A-C,E-F,H) Synergy; (I-J) single agent venetoclax activity; (D,G) antagonism.