Study overview. 1. Early progression is defined as progression or death within 2 years after registration. One additional patient was excluded from this set of analyses, who withdrew consent after 50 days from registration. 2. CAC seen in >5 patients. 3. Regions identified through SPP analysis with log-rank statistics using Nexus (see “Methods”). P < .01 was used as a cutoff for the Fisher exact test for early progression, and univariate and multivariate Cox analyses for PFS and OS.