Coactivation of NF-κB and Notch signaling downregulates lymphoma and myeloid gene suppressor Bach2 and upregulates genes regulating stemness in MZPs. (A) RNA-seq analyses (n = 2 biological replicates for each genotype) of flow-sorted MZPs from control (Con), TriB, or NIK mice, MZBs from Notch mice, and transformed lymphoma cells (TriB[lym]). Heatmaps were generated from selected genes of interest. (B) GSEA showed gene sets enriched in TriB or Con MZPs. (C-D) Relative expression of Bach2 (C) and Cebpα (D) in Con MZPs (CMZP), TriB MZPs (TMZP), TriB(lym), or converted myeloid leukemia (Bswitch) cells (n = 3). (E) The expression of Bach2 proteins in Con and TriB B cells, TriB(lym), and Bswitch leukemia cells (n = 3). **P < .01. FDR, false-discovery rate.