Analysis of B-cell lymphomas in transgenic mice. (A) Volcano plot of differential gene expression in group II vs group I tumor samples. Same B-cell lymphomas as in Figure 4A. The numbers of significantly upregulated (in blue) and downregulated (in orange) genes are shown. (B) Heat map of the 100 most variable gene expressions across all tumor samples; hierarchical clustering of genes/samples according to Pearson’s correlation metric and Ward’s method. Same symbols, colors, and group definitions as in Figure 4A. (C) Number of RNAseq samples in each group according to genotype. P value from Fisher’s exact test. (D) Summary of GSEA analysis of differential gene expression: top 5 enriched GO biological processes (false discovery rate <0.05, size >80) for both groups. (E) Detailed GSEA analysis of differentially expressed genes against human BL signatures (up- and downregulated genes from Hummel et al²⁶  [left] and from Sha et al²⁷  [middle and right]) defined by BL vs germinal center (GC) B-cell like DLBCL (left), BL vs HGBVL (middle), or BL vs GC-DLBCL (right) comparisons.