Inference of putative multilineage contributions from HSPCs. (A) Schematic diagram of HSPCs (unobserved) and 6 populations of cells that were sorted using fluorescence activated cell sorting. (B) Examples of cell type–specific mutations in vivo across up to 240 days of evaluation. Donor is indicated at the top of the panel (eg, CLL7). (C) Heteroplasmy of 6453T>C allele in donor CLL5; this is a CD19⁺CD5⁻ B-cell–specific mutation that decreases in frequency over 150 days of observation. (D) Mutations in 2 donors that are present in both CD19⁺CD5⁺ (CLL) cells and CD19⁺CD5⁻ B cells. Arrow highlights 1 observed CD19⁺CD5⁻ sample. (E) Examples of shared CLL and B-cell mutations that decay at different rates for 2 donors.